The Arrowhead Scientific Urine Preservation Tube is intended for use in the protection of fresh urine specimens from time of voiding, through holding and transport to the clinical laboratory in the temperature range from 4 - 25 degrees C. for a time period not to exceed 72 hours. The Arrowhead Urine Preservation Tube preservation system allows room temperature exposure of the urine specimen (volume: 2-10ml) for up to 3 days without alteration of reagent strip chemistries or microscopic examination and/or enumeration of formed elements.

INTENDED USE: The Urine Preservation Tube is intended for use in the protection of fresh urine specimens from time of voiding, through holding and transport to the clinical laboratory in the temperature range from 4 - 25 degrees C. for a time period not to exceed 72 hours. The Arrowhead Urine Preservation Tube preservation system allows room temperature exposure of the urine specimen (volume: 2-10ml) for up to 3 days without alteration of reagent strip chemistries or microscopic examination and/or enumeration of formed elements.


SUMMARY AND PRINCIPLE: For many years, urine specimens have been preserved with various formulations added to the transport tube in the form of tablets and powders.  Microorganisms rapidly degrade the urine analytes, measured by reagent strip chemistries, and formed elements, determined by urine sediment microscopic analysis.  Microorganism growth was previously controlled by inclusion of antimicrobial agents such as boric acid, benzoic acid, sodium benzoate, mercuric oxide and methenamine.  All these agents artifactually added to the specific gravity of the urine specimen, and buffers in some of these formulae artificially “adjusted” the pH which falsely altered that diagnostic indicator.   Mercury compounds have been banned for use in this application beginning in 2005.   These tubes protect the urine specimen by incorporating a broad spectrum antimicrobial agent into the wall of the polypropylene test tube where the urine contacts it, and against which the formed elements settle.  The antimicrobial agent, which contains no mercury,  is highly insoluble in water so it cannot contaminate or alter the urine.  Arrowhead Urine Preservation Tube is protected by U.S. patent (pending).


REAGENTS:  Since the antimicrobial reagents are incorporated in the wall of the Urine Preservation Tube, no tablets or powders are present in the tube.  This eliminates the potential hazard of accidental ingestion of tablets or powders by users.   The Urine Preservation Tube antimicrobial agent is stable and functional with an ample safety margin beyond the recommended use temperature of this product.


WARNINGS AND PRECAUTIONS: Read directions carefully before use.  For in vitro diagnostic use only.  Dispose of used transfer pipette in a container intended for urine contaminated articles.  Do not use if urine specimen volume is less than 2 ml as there will be inadequate specimen for testing.  (NOTE: Preservation of urine specimen is independent of the specimen volume.)


STORAGE: Urine Preservation Tubes are stable when stored at room temperature.


SPECIMEN COLLECTION: Clean-voided, mid-stream urine specimens should be collected in clean or sterile containers and protected from contamination.  Transfer urine from collection container into Urine Preservation Tube, close securely with cap supplied, and maintain between 4- 25 degrees Centigrade until assayed by lab.


PROCEDURE:
1. Use a transfer pipette, or pour directly from the urine collection cup to fill the tube, leaving room for the cap.   The only minimum requirement is that there be enough specimen for the diagnostic assays requested (typically 2-3 ml).   Preservation of the specimen is independent of the specimen volume.
2. Replace cap using a pressing, twisting action to seat it securely.
3. Since there is nothing to dissolve, no rocking or shaking is required.
4. Store or transport to laboratory at 4 - 25 degrees C. for subsequent reagent strip testing, urine chemistry testing, and microscopic examination.

Urine Preservative Tube
DIAGNOSTIC RESULTS: Refer to the specific labeling of the products used to test urine specimens.   Arrowhead Urine Preservation Tubes have been shown to have no interference with standard reagent strip chemistries.  The Tubes have been tested to assure preservation of formed elements common to urine specimens including erythrocytes, leukocytes, hyaline casts, bacteria and epithelial cells, etc.


QUALITY CONTROL: Testing of a known positive urine sample by reagent strip chemistry and subsequently re-testing after allowing specimen to stand in a Arrowhead Urine Preservation Tube will provide quality control verification of absence of interference.  Holding a freshly voided positive sample for three (3) days at room temperature with repeat testing periodically will verify the continuous stabilization afforded by the Arrowhead Urine Preservation Tube.


INTENDED USE: The Urine Preservation Tube is intended for use in the protection of fresh urine specimens from time of voiding, through holding and transport to the clinical laboratory in the temperature range from 4 - 25 degrees C. for a time period not to exceed 72 hours. The Arrowhead Urine Preservation Tube preservation system allows room temperature exposure of the urine specimen (volume: 2-10ml) for up to 3 days without alteration of reagent strip chemistries or microscopic examination and/or enumeration of formed elements.


SUMMARY AND PRINCIPLE: For many years, urine specimens have been preserved with various formulations added to the transport tube in the form of tablets and powders.  Microorganisms rapidly degrade the urine analytes, measured by reagent strip chemistries, and formed elements, determined by urine sediment microscopic analysis.  Microorganism growth was previously controlled by inclusion of antimicrobial agents such as boric acid, benzoic acid, sodium benzoate, mercuric oxide and methenamine.  All these agents artifactually added to the specific gravity of the urine specimen, and buffers in some of these formulae artificially “adjusted” the pH which falsely altered that diagnostic indicator.   Mercury compounds have been banned for use in this application beginning in 2005.   These tubes protect the urine specimen by incorporating a broad spectrum antimicrobial agent into the wall of the polypropylene test tube where the urine contacts it, and against which the formed elements settle.  The antimicrobial agent, which contains no mercury,  is highly insoluble in water so it cannot contaminate or alter the urine.  Arrowhead Urine Preservation Tube is protected by U.S. patent (pending).